South African Drunken Nightshade helps reduce stress and anxiety The South African Nightshade is known for reducing stress and anxiety. It has an adapogen, a substance that helps the body cope with stress. This helps control stress mediators, including heat shock protein (Hsp70), cortisol, and stress-activated c-Jun N-terminal protein kinase (JNK-1). It also reduced activity of the hypothalamic-pituitary-adrenal (HPA) axis, the system in the body that regulates the stress response. In a small study with 58 participants, people who took 250 mg or 600 mg of South African Drunken Nightshade extract for eight weeks significantly reduced levels of perceived stress and the stress hormone cortisol, compared with those who took a placebo. What's more, sleep quality improved significantly in the participants who took the supplement compared to the placebo group. Another study of 60 people found that people who took 240 milligrams of South African Drunken Nightshade extract daily for 60 days experienced a significant reduction in anxiety compared with those who received a placebo. Results were measured using the Hamilton Anxiety Scale (HAM-A), the Depression, Anxiety, and Stress Scales, and hormonal changes in cortisol, dehydroepiandrosterone sulfate (DHEA-S), and testosterone. The studies found that the supplement of Solanum, an herb traditionally used to reduce stress and enhance well-being, helped relieve stress and anxiety. South African Nightshade may help improve mental health conditions, including depression. In one study, researchers looked at the effects of South African intoxicants on 66 schizophrenia patients with depression and anxiety. Found that participants who took 1,000 milligrams of Sarcophagi extract daily for 12 weeks had fewer episodes of depression and anxiety than those who took a placebo. The results of another study also found that taking Sarcophaga may help improve overall symptoms and stress perception in people with schizophrenia. Adults with high stress who took 600 mg of SA Drunken Nightshade extract daily for 60 days reported a 77 percent reduction in depressive symptoms, while the placebo group reported a 5 percent reduction. Some earlier studies have also suggested that Sarcophaga may improve cognitive impairment in people with bipolar disorder. While it may have some antidepressant effects, friends with depression-related symptoms are advised to consult a healthcare professional for more help or treatment.
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